Anlagenentwicklung und -validierung zur Herstellung elektrogesponnener Garne für den Einsatz im Tissue Engineering

  • Machine development and validation for the production of electrospun yarns for tissue engineering applications

Kruse, Magnus Hinrich; Gries, Thomas Gerhard (Thesis advisor); Jockenhövel, Stefan (Thesis advisor)

Düren : Shaker (2019)
Book, Dissertation / PhD Thesis

In: Textiltechnik/Textile technology
Page(s)/Article-Nr.: IV, 241 Seiten : Illustrationen , Diagramme

Dissertation, RWTH Aachen University, 2019


Tissue Engineering is a field of research that combines physical, chemical, biological and engineering processes to produce living tissue for medical purposes. The scaffold is an essential factor in this process, serving as a supporting structure for the cells and promoting correct tissue formation. An exact reproduction of the body's extracellular matrix is an advantage. The development of the scaffolds takes place within the framework of engineering research. The task is to produce a scaffold that meets the requirements of the cells, taking into account the correct material and process selection. In comparison to other textile pro-cesses, electrospinning is of particular interest as it simulates the structure of the extracellular matrix and thus provides an ideal environment for the cultivation of cells. The deficit of the conventional electrospinning process is the limitation to two-dimensional nonwoven structures. Therefore, the aim of this work is the development and subsequent validation of a production process for the manufacture of electrospun yarns, in order to be able to combine the advantages of e-spun fibres for applications in the field of tissue engineering with the properties of textile technology products. For this reason, an e-yarn spinning plant will be constructed in the first step of the work. For the machine validation a mixture of the polymers polylactic acid (PLA) and polyethylene glycol (PEG) is transformed into electrospun yarns. Furthermore, it is proven that the spinning plant can be used universally by the production of electro-spun yarns from thermoplastic polyurethane. Process speeds of up to 1.3 m/min are achieved during yarn production from PLA and PEG. These yarns are then further processed in the knitting and weaving process. A processing of the yarns in an automated textile process can thus be demonstrated within the scope of the work. On the basis of the produced woven fabric, a final concept is developed for transferring the results into industry.