Verstärkungsstrukturen für den Einsatz im myokardialen Tissue Engineering

  • Reinforcement structures for use in myocardial tissue engineering

Bolle, Tim; Gries, Thomas Gerhard (Thesis advisor); Jockenhövel, Stefan (Thesis advisor)

Düren : Shaker Verlag (2019)
Book, Dissertation / PhD Thesis

In: Textiltechnik/Textile technology
Page(s)/Article-Nr.: IV, 278 Seiten : Illustrationen, Diagramme

Dissertation, RWTH Aachen University, 2019

Abstract

Heart transplantation and the use of ventricular assist devices as destination therapy are available for the treatment of terminal heart failure. Only 0.2% of those affected are on the waiting list for a donor heart. The average life expectancy with ventricular assist devices as destination therapy is very low at two to four years. Myocardial tissue engineering offers an alternative therapy option. With regard to successful translation into the clinic, the upscaling of patches or replacement structures remains the greatest challenge. Deficits are the lack of a functional vascular network and the mechanical instability of the structures. The aim of the work is therefore to establish a reinforcement technology for the load-appropriate design of myocardial patches. Based on the requirements, the most suitable technology for the production of reinforcement structures is selected. In the course of the investigation of the manufacturing process, the relevant morphological and mechanical properties of the reinforcement structures are evaluated and compared with the characteristics of the human muscle. Finally, the biocompatibility and the pre-vascularization potential of the reinforcing structures are investigated within in vitro experiments. Warp knitted spacer fabrics are selected as the most suitable reinforcement structures. The investigation of the manufacturing process shows that the relevant morphological and mechanical characteristics of the knitted fabrics can be adjusted in a wide range. Selected structures show a high compliance with the characteristics of human heart muscle. In addition, the spatial formation of tubular structures inside the reinforcing structure can be demonstrated. Spacer fabrics therefore represent an ideal component for the scaling of tissue-engineered patches or replacement structures for the successful translation of novel therapies, such as the treatment of terminal heart failure with the aid of textile-reinforced myocardial patches, into the clinic.

Identifier

  • ISBN: 3-8440-7030-3
  • ISBN: 978-3-8440-7030-9
  • RWTH PUBLICATIONS: RWTH-2019-10575