Inkorporation von Mikrogelen in Polylactid-co-Glycolid-Filamente mittels Nassspinnverfahren

  • Incorporation of microgels into polylactid-co-glycolid-filaments by wet spinning

Paar, Georg-Philipp; Gries, Thomas (Thesis advisor); Jockenhövel, Stefan (Thesis advisor)

Düren : Shaker (2021)
Book, Dissertation / PhD Thesis

In: Textiltechnik/Textile technology
Page(s)/Article-Nr.: IV, 220 Seiten : Illustrationen, Diagramme

Dissertation, RWTH Aachen University, 2021

Abstract

By use of bioresorbable polymers in implants it is possible to avoid second op-erations for implant removal and long-term complications, as well as the gradual transition of the load to the healing tissue. In the field of medical textiles, these materials are established for sutures and meshes and are increasingly used in the field of tissue engineering. The most frequently used bioresorbable polymers are to be found in the group of poly(α-hydroxycarbonic acids). Degradation of these polymers result in the release of acidic degradation products, which in vivo lead to a local decrease in pH, acidosis, and subsequently to increased foreign body reactions. In past studies, the reduction of the pH drop through the in-corporation of buffering, colloidal polymer networks, microgels, has been identified as promising. However, further processing of filaments made of this material combination is severely limited due to low tensile strength. The aim of the present work is therefore to develop filaments with reduced pH drop during degradation and to demonstrate the further processing of these. For this purpose, the mechanical and biological requirements on the filament are defined for the application examples "suture" and "scaffold". Based on evaluation criteria and preliminary tests, the wet spinning process is selected as the manufacturing method and PLGA Purasorb PLG8523 as the material. The influence of relevant process parameters and the incorporation of microgels on the filament properties and on the degradation behaviour of these is systematically determined. Fields of application for an economic exploitation of the development are identified and evaluated. The processing of filaments with a microgel loading of 2.5 wt.% into braids, woven and knitted fabrics is successful. However, a buffering effect of the microgels is not detectable, which is attributed to the insufficient buffering capacity of the microgel mass introduced. The observed increase in the degradation rate due to the incorporation of the microgels must be taken into account when de-signing resorbable implants.

Identifier

  • ISBN: 3-8440-8058-9
  • ISBN: 978-3-8440-8058-2
  • RWTH PUBLICATIONS: RWTH-2021-05644